解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Elk is a member of the eph family of receptor-like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expre...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420207
更新日期:1995-10-01 00:00:00
abstract::GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420113
更新日期:1995-09-01 00:00:00
abstract::The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in ho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420103
更新日期:1995-09-01 00:00:00
abstract::SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410609
更新日期:1995-08-15 00:00:00
abstract::Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410506
更新日期:1995-08-01 00:00:00
abstract::This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410516
更新日期:1995-08-01 00:00:00
abstract::GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410408
更新日期:1995-07-01 00:00:00
abstract::C6 cells were adapted to proliferate in defined culture medium to allow the study of long-term effects of serum-free growth conditions on their phenotypic antigen expression and production of neurite promoting factors (NPFs). Cultures were grown in either Ham's F-12 or supplemented Opti-MEM-I containing 15% heat-inact...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410310
更新日期:1995-06-15 00:00:00
abstract::In the following review, we address difficulties that have arisen when attempting to convert the myelin multilayers into vesicles. The emphasis is on CNS myelin of adult mammals although both central nervous system (CNS) and peripheral nervous system (PNS) myelin are considered. The ability to prepare vesicle of myeli...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490410202
更新日期:1995-06-01 00:00:00
abstract::Tissue culture media with serum generally cause excessive astrocyte proliferation in neonatal brain cultures, and often fail to support neonatal neurons. Published serum-free media for brain cultures contain sodium pyruvate, which interferes with lactate dehydrogenase (LDH) assays for cell death. We wanted to use neon...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410212
更新日期:1995-06-01 00:00:00
abstract::In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410110
更新日期:1995-05-01 00:00:00
abstract::The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410113
更新日期:1995-05-01 00:00:00
abstract::To study the sequence of degenerative events possibly associated with cholinergic cell death in Alzheimer's disease, septal cholinergic neurons derived from rat embryonic brains were exposed to chronic excitotoxic stress by glutamate. Counts of choline acetyltransferase (ChAT)-immunopositive neurons and measurement of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400608
更新日期:1995-04-15 00:00:00
abstract::A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81-kDalton glycoprotein in buffer-soluble and detergent-solubilized rat brain extracts (BE). The glycoprotein was more abundant in extracts prepared from injured brain than in thos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400609
更新日期:1995-04-15 00:00:00
abstract::Transection of the hindlimb dorsal column fibers leads to a partial deafferentation of the neurons of the nucleus gracilis, the first relay of the ascending dorsal column-medial lemniscal (DC-ML) neural network. In response to the deafferentation, a synaptic renewal cycle is initiated and the neurons of the nucleus gr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400409
更新日期:1995-03-01 00:00:00
abstract::Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400310
更新日期:1995-02-15 00:00:00
abstract::The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400205
更新日期:1995-02-01 00:00:00
abstract::Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400216
更新日期:1995-02-01 00:00:00
abstract::A number of cytokines and growth factors may affect astrocyte proliferation and functions. Transforming growth factor-beta 1 (TGF-beta 1) is a pleiotropic cytokine which exerts multiple effects on growth and differentiation of different cell types. TGF-beta 1 is present in low amounts in the normal brain. TGF-beta 1 g...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400114
更新日期:1995-01-01 00:00:00
abstract::Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400111
更新日期:1995-01-01 00:00:00
abstract::The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390604
更新日期:1994-12-15 00:00:00
abstract::The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390506
更新日期:1994-12-01 00:00:00
abstract::The transforming growth factors beta (TGF-beta), a family of regulatory polypeptides, are involved in numerous vital processes including inflammation and wound healing. Since repair of a peripheral nerve lesion includes a series of well-defined steps of cellular actions possibly controlled by TGF-beta s, and since TGF...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390408
更新日期:1994-11-01 00:00:00
abstract::Myelin gene expression in normal oligodendrocytes (OLG) depends on developmentally regulated protein kinase C (PKC) enzyme activity (Asotra and Macklin: J Neurosci Res 34:571-588, 1993). We studied the developmental expression of the Ca(++)-dependent PKC-alpha, -beta 1, -beta II and -gamma isozymes, and the Ca(++)-ind...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390305
更新日期:1994-10-15 00:00:00
abstract::Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390212
更新日期:1994-10-01 00:00:00
abstract::The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on b...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390105
更新日期:1994-09-01 00:00:00
abstract::It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380605
更新日期:1994-08-15 00:00:00
abstract::Acetylcholinesterase (AChE) molecular forms were studied in normal (NM) and in dystrophic (DM) 129B6F1/J mouse muscle. Successive extractions of the tissue with saline and saline-Triton X-100 buffers yielded two soluble fractions, S1 and S2. Forty percent of the AChE in NM was measured in S1 and 60% in S2, and 65% and...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380504
更新日期:1994-08-01 00:00:00
abstract::Injury to the central nervous system (CNS) either from trauma or due to demyelinating/degenerating diseases results in a typical response of astrocytes, termed astrogliosis. This reaction is characterized by astrocyte proliferation, extensive hypertrophy of nuclei, cell body, and cytoplasmic processes and an increase ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380403
更新日期:1994-07-01 00:00:00
abstract::The ED1 monoclonal antibody recognizes an antigen in lysosomal membranes of phagocytes. The expression of this antigen in cells increases during phagocytic activity. Here we describe the expression of ED1-immunoreactivity during the various stages of both acute (monophasic) and chronic relapsing experimental autoimmun...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380402
更新日期:1994-07-01 00:00:00
abstract::Drebrins are developmentally regulated actin-binding proteins. In this study, we analyzed subcellular distribution of drebrin E in neuroblastoma cells (SH-SY5Y) in culture, especially in terms of its relationship to actin filaments. In undifferentiated cells, drebrin E was scattered as flocculus small dots along the s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380205
更新日期:1994-06-01 00:00:00
abstract::Astrocytes purified from the neonatal rat brain were cultured for up to 3 weeks prior to being treated with agents that can induce reactive changes in astrocytes. These agents included dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned media. After treating astrocytes for 3 days, the agents were removed an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380108
更新日期:1994-05-01 00:00:00
abstract::The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370512
更新日期:1994-04-01 00:00:00
abstract::Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370508
更新日期:1994-04-01 00:00:00
abstract::Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370405
更新日期:1994-03-01 00:00:00
abstract::Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370310
更新日期:1994-02-15 00:00:00
abstract::In many regions of the rat central nervous system, oligodendrocytes develop from migratory A2B5+ precursor cells. In the rat spinal cord, during early embryonic development the capacity for oligodendrogenesis appears to be restricted to ventral regions of the spinal cord, while cultures of postnatal rat spinal cord co...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370208
更新日期:1994-02-01 00:00:00
abstract::Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370117
更新日期:1994-01-01 00:00:00
abstract::In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360509
更新日期:1993-12-01 00:00:00
abstract::The growth and differentiation of neural precursor cells in the central nervous system (CNS) are regulated by their response to polypeptide growth factors which interact with specific transmembrane receptor tyrosine kinases (RTKs). We demonstrate that rat oligodendrocyte-type 2 astrocyte (O-2A) glial progenitor cells,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360512
更新日期:1993-12-01 00:00:00